A closer location that has some beautiful scenery and would give you a good workout would be a trip through Yosemite National Park on Hwy 120 going west to east.
Start at the intersection of Hwy 120 and Hwy 149 follow hwy 120 through the park to the intersection of hwy 120 and 395 near the Lee Vining airport.
Total trip is just a hair short of a century at 98.9 miles. Start is at 886ft in elevation and the highest point is 9974 ft in elevation. Total climb is 18,062 total descent is a drop of 12,073.
Here is a link to the route on ride with gps.
Yosemite ? Tuolumne, CA US
Here are some pics of what you will get to see.