Did you sit fairly upright on that Cannondale? (judging from the seat/handlebar height)
On my Motobecane, the seat seems like it is jacked up to the sky in the pics, yet it feels super comfortable to ride, and my arms don't get tired/hands don't go numb.
I guess it seems that way because the top tube angles down so much at the rear.
I'll have to get some better "straight in from the side" pics & also measure the difference in seat height as compared to the handlebars. I would think this is an important consideration to be aware of, especially if you are prone to hand issues.