Were you sick for the full three weeks, or just off your bike for that time? If it was the former, I would suggest a trip to the doctor before pushing yourself.
Other than that, you'll need to work your way back up incrementally, depending on how you feel. If it was me, I'd put some easy miles in first, to make sure my legs are ready to get back in the game. Then I would put in some longer, moderate speed miles, eventually adding some intervals into the last 3rd of each ride, building to 3x hard intervals per week, with rest between. No hard intervals in the week before the century. Feel free to modify that plan to suit your own needs. But that's probably what I shoot for.
As always, get a second opinion before you take any advice.