I prefer using double sided pedals; I went with the Shimano M520 pedal (mountain bike pedal) with Specialized MTB Comp shoes. My thought process is several fold.
One, double sided pedal. I'm a commuter and don't like the idea of trying to flip my pedal to clip in when some Bieber-fever induced Iphone toting txting teen is about to run me over. The double sided pedals, step down and you're in.
I chose mountain shoes because as a commuter, I need to be able to walk once I get to where I am. You can walk in road shoes, sure, but I find MTB shoes easier to walk in.
I use a set of Shimano pedals on my hybrid as well, maybe the M530? It's a clipless pedal, but also has a cage/platform so you can ride them in plain shoes althought you do feel it through the sole of your sneakers.
I would have gone with speedplay, but honestly, with the cost of the M520s and the bulletproof reliability (in my experience and LBS's experience) it was a no brainer.
I'm not a weight weenie so a few hundred grams doesn't keep me up at night.
"Then God created the bicycle so that man has the instrument of fatigue and excitement in the difficult journey of life .."