I don't -- only know that some folks who experience numbness in their nether regions from regular saddles evidently get relief from nose-less saddles. On the other hand, I believe being nose-less has some drawbacks also, such as a greater possibility of sliding off the saddle and having the afore-said nether regions land on the top tube.
I have tried the ISM Typhoon and didn't find much improvement over a good hard conventional saddle with a large cut out/deep center groove. I am happy with an SMP saddle on my spin bike and Specialized Romin and Koobi split nose saddles on my road bikes.
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